Intraoral Sialadenoma Papilliferum: A Comprehensive Review of the Literature with Emphasis on Clinical and Histopathological Diagnostic Features

Background. Sialadenoma papilliferum (SP) is a rare benign epithelial tumor of salivary gland origin, its diagnosis being potentially challenging. It was first described by Abrams and Finck in 1969 as an analog the cutaneous syringocystadenoma papilliferum. The aim this comprehensive review to highlight clinical histopathological diagnostic aspects intraoral SP, analyzing cases previously reporting new cases. Methods. Medline, Scopus, Web Science were searched up February 2022, using entry term “sialadenoma papilliferum”. No time limits applied only studies English taken into account. Only involving mouth included. Conference proceedings, personal communications, letters editor excluded. Results. In total, 42 out 234 articles fulfilled inclusion criteria, with 64 reported. Mean age patients SP 57.2 years, higher prevalence among males. most affected site palate, particularly hard palate. Four uncertain malignant features have been While manifestations are rather unspecific (e.g., submucosal swelling ulceration), immunohistochemical quite peculiar, limited growth potential, leading conservative excision treatment choice. Conclusions. though rare, should be consideration differential swellings, those located on